MEA has been the gold standard for QC in the IVF laboratory for many years.
It has been demonstrated by many key opinion leaders as the most optimal bioassay to detect toxins in raw materials, media, and other contact materials. Some opinion leaders have even demonstrated that within the MEA quality control test, the One-Cell test is more sensitive than the Two-Cell test and even more sensitive than the HSSA.
(Davidson, A., Vermesh, M., Lobo, R. and Paulson. R. Mouse embryo culture as quality control for human in vitro fertilization: the one-cell versus the two-cell model. Fertil Steril 1988; 49: 516-21) ( Morbeck. D.E., Khan, Z., Barnidge, D.R. and Waljer, D.L. Washing mineral oil reduces contaminants and embryotoxicity. Fertil Steril 2010; 94: 2747-52) (Hughes, P. M., Morbeck, D. E., Hudson, S., Fredrickson, J., Walker, D.L. et al. Peroxides in mineral oil used for in-vitro fertilization: defines limits of standard quality control assays. J. Assist Reprod Genet 2010; 27: 87-92)